The insomniac’s mind

Brain scans of people who say they have insomnia have shown differences in brain function compared with people who get a full night’s sleep.images

Researchers at the University of California, San Diego, said the poor sleepers struggled to focus part of their brain in memory tests, reports the BBC

“Other experts said that the brain’s wiring may actually be affecting perceptions of sleep quality. The findings were published in the journal Sleep. People with insomnia struggle to sleep at night, but it also has consequences during the day such as delayed reaction times and memory. The study compared 25 people who said they had insomnia with 25 who described themselves as good sleepers. MRI brain scans were carried out while they performed increasingly challenging memory tests. One of the researchers, Prof Sean Drummond, said: “We found that insomnia subjects did not properly turn on brain regions critical to a working memory task and did not turn off ‘mind-wandering’ brain regions irrelevant to the task.

“This data helps us understand that people with insomnia not only have trouble sleeping at night, but their brains are not functioning as efficiently during the day.” A sleep researcher in the UK, Dr Neil Stanley, said that the quality of the sleep each group was having was very similar, even though one set was reporting insomnia. He said: “What’s the chicken and what’s the egg? Is the brain different and causing them to report worse sleep? “Maybe they’re perceiving what happened in the night differently; maybe what is affecting their working memory and ability to focus on the task at hand is also causing insomnia.”

 

More at: http://www.bbc.co.uk/news/health-23897665

Insomnaics for drugs

Every now and then everyone has trouble sleeping. And then there are those of us who always have the problem.

No wonder the sleep medication industry now accounts for $1.7-billion in spending each year.

Todays Wall Street Journal discusses “A new sleep drug by Merck & Co. is expected to gain U.S. approval in the coming months, even as its main competitor is coming under growing scrutiny by regulators and doctors for sometimes-dangerous side effects. The new drug, known as suvorexant, will affect a different part of the brain than a generation of older medicines such as zolpidem, known as Ambien, which depresses brain activity. The hope is that suvorexant will cause fewer side effects than its older counterparts.

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“An estimated 25% or more Americans face a bout of insomnia in a given year, and at least 1 in 10 suffers the chronic form of the disorder, routinely facing sleepless nights, according to the Centers for Disease Control and Prevention.

“There’s a need for more drugs,” said Russell Rosenberg, chairman of the National Sleep Foundation. Current drugs don’t work for everyone, and a push to lower doses amid safety concerns has led to patients “coming in and saying it’s not working as well,” said Dr. Rosenberg, a practicing sleep psychologist and director of the Atlanta School of Sleep Medicine and Technology.

“New sleep drugs may be facing a higher approval bar, amid rising concern that Ambien and similar drugs cause side effects such as risky bouts of sleepwalking and next-day drowsiness, which can impair driving. The U.S. Food and Drug Administration advised doctors to reduce doses of Ambien for women, and added new warnings to its labeling earlier this year.”

 

Read full article at: http://online.wsj.com/article/SB10001424127887324183204578565392659897114.html