Tag: Alzheimer’s

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Dementia villages

Centuries after Shakespeare wrote about King Lear’s symptoms, there’s still no perfect way to care for sufferers of dementia and Alzheimer’s. In the Netherlands, however, a radical idea is being tested: Self-contained “villages” where people with dementia shop, cook, and live together—safely.

We, as a population, are aging rapidly. According to the Alzheimer’s Association, one in three seniors today dies with dementia. The process of finding—and paying for—long-term care can be very confusing, unfortunately, and difficult for both loved ones and patients. Most caretakers are underpaid, overworked, and must drive far distances to their jobs—giving away some 17 billion unpaid hours of care a year. And it’s just going to get worse: Alzheimer’s has increased by an incredible 68 percent since 2000, and the cost of caring for sufferers will increase from $203 billion last year to $1.2 trillion by 2050.

In short, we’re not prepared for the future that awaits us—financially, infrastructurally, or even socially. But in the small town of Weesp, in Holland—that bastion of social progressivism—at a dementia-focused living center called De Hogeweyk, aka Dementiavillage, the relationship between patients and their care is serving as a model for the rest of the world.

Hogeweyk, from a certain perspective, seems like a fortress: A solid podium of apartments and buildings, closed to the outside world with gates and security fences. But, inside, it is its own self-contained world: Restaurants, cafes, a supermarket, gardens, a pedestrian boulevard, and more.

The idea, explains Hogeweyk’s creators, is to design a world that maintains as much a resemblance to normal life as possible—without endangering the patients. Continue reading “Dementia villages”

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Largest Alzheimer’s DNA study results

A clearer picture of what causes Alzheimer’s disease is emerging after the largest ever analysis of patients’ DNA, reports the BBC today.images

“A massive international collaboration has now doubled the number of genes linked to the dementia to 21. The findings, published in the journal Nature Genetics, indicate a strong role for the immune system.

“Alzheimer’s Research UK said the findings could “significantly enhance” understanding of the disease. The number of people developing Alzheimer’s is growing around the world as people live longer. However, major questions around what causes the dementia, how brain cells die, how to treat it or even diagnose it remain unanswered.

“It is really difficult to treat a disease when you do not understand what causes it,” one of the lead researchers, Prof Julie Williams from Cardiff University, said. The genetic code, the instructions for building and running the body, was scoured for clues. A group – involving nearly three quarters of the world’s Alzheimer’s geneticists from 145 academic institutions – looked at the DNA of 17,000 patients and 37,000 healthy people. They found versions of 21 genes, or sets of instructions, which made it more likely that a person would develop Alzheimer’s disease. They do not guarantee Alzheimer’s will develop, but they do make the disease more likely. By looking at the genes’ function in the body, it allows researchers to figure out the processes going wrong in Alzheimer’s disease. Prof Williams, the head of neurodegeneration at Cardiff University, told the BBC: “We’ve doubled the number of genes discovered and a very strong pattern is emerging.”There is something in the immune response which is causing Alzheimer’s disease and we need to look at that.” Continue reading “Largest Alzheimer’s DNA study results”

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It’s not Alzheimer’s

Scientists have good news for all the older adults who occasionally forget why they walked into a room – and panic that they are getting Alzheimer’s disease, reports Reuters.

“Not only is age-related memory loss a syndrome in its own right and completely unrelated to that dread disease, imgres-1but unlike Alzheimer’s it may be reversible or even preventable, researchers led by a Nobel laureate said in a study published on Wednesday.

“Using human brains that had been donated to science as well as the brains of lab mice, the study for the first time pinpointed the molecular defects that cause cognitive aging.

“In an unusual ray of hope for a field that has had almost nothing to offer older adults whose memory is failing, the study’s authors conclude that drugs, foods or even behaviors might be identified that affect those molecular mechanisms, helping to restore memory.

“Any such interventions would represent a significant advance over the paltry offerings science has come up with so far to prevent memory decline, such as advice to keep cognitively active and healthy – which helps some people, but not all, and has only a flimsy scientific foundation. By identifying the “where did I park the car?” molecule, the discovery could also kick-start the mostly moribund efforts to develop drugs to slow or roll back the memory lapses that accompany normal aging.

“This is a lovely set of studies,” said Molly Wagster of the National Institute on Aging, an expert on normal age-related memory decline who was not involved in the new study. “They provide clues to the underlying mechanism of age-related memory decline and will, hopefully, move us down the road toward targeted therapeutics.” Continue reading “It’s not Alzheimer’s”

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Dementia’s early warning system

The man complained of memory problems but seemed perfectly normal. No specialist he visited detected any decline, begins a frightening story in today’s New York Timesimages

“He insisted that things were changing, but he aced all of our tests,” said Rebecca Amariglio, a neuropsychologist at Brigham and Women’s Hospital in Boston. But about seven years later, he began showing symptoms of dementia. Dr. Amariglio now believes he had recognized a cognitive change so subtle “he was the only one who could identify it.”Patients like this have long been called “the worried well,” said Creighton Phelps, acting chief of the dementias of aging branch of the National Institute on Aging. “People would complain, and we didn’t really think it was very valid to take that into account.”

“But now, scientists are finding that some people with such complaints may in fact be detecting early harbingers of Alzheimer’s.Studies presented Wednesday at an Alzheimer’s Association conference in Boston showed that people with some types of cognitive concerns were more likely to have Alzheimer’s pathology in their brains, and to develop dementia later. Research presented by Dr. Amariglio, for example, found that people with more concerns about memory and organizing ability were more likely to have amyloid, a key Alzheimer’s-related protein, in their brains. Continue reading “Dementia’s early warning system”

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Alzhheimer’s, dementia, and stigma

In a time of medical breakthroughs, where cures are created for many conditions that were once terminal, it’s easy to forget that some conditions are still incurable and almost impossible to prevent or slow down, reports the Irish Times.

“Longer life expectancy means that by 2041 there will be 1.4 million people in Ireland aged 65 and over, making up 22 per cent of the population.

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“Dementia and old age go hand in hand so the number diagnosed with dementia is expected to increase three-fold to more than 120,000 in the next 30 years. Currently, there are nearly 42,000 people living with dementia in Ireland.

“Alzheimer’s disease, a common form of dementia, causes memory loss and there is very little medically that can be done. Certain drugs may slow down the progression of the condition, but they are not a cure. The World Alzheimer Report 2012 looked at the stigma attached to dementia and Alzheimer’s. Families and friends often don’t know how to deal with it, which creates feelings of isolation and exclusion for people with dementia.  Continue reading “Alzhheimer’s, dementia, and stigma”

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The science of forgetting

As the baby boom generation ages towards retirement, attention grows over how people can remain mentally sharp. Alzheimer’s and other forms of dementia make  boomers start to worry when they lose their car keys or stumble over a name. At the same time, Internet search engines
 and home data storage have made the actual need to remember less important. Add to this the rapid pace of media and the public’s seemingly relentless focus on immediacy over history, and it seems like a wholesale assault on memory is sweeping the culture. So a story like “The Forgetting Pill Erases Painful Memories” recently appearing in Wired magazine would seem to support the current culture of amnesia. Continue reading “The science of forgetting”